LYRIC/AEG-1 (Astrocyte Elevated Gene 1)/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium .Differential subcellular localization and overexpression of LYRIC/AEG-1/MTDH has been seen in multiple human cancers. LYRIC/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis . In breast cancer, increased LYRIC/AEG-1/MTDH may confer increased chemoresistance as well as metastasis. LYRIC/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) and glioblastoma multiforme (GBM).
