Thioredoxins comprise a family of small proteins that, by catalyzing the oxidation of disulfide bonds, participate in redox reactions throughout the cell. TRP14 (thioredoxin-related protein 14), also known as Protein 42-9-9, TXNL5 or TXNDC17, is a 123 amino acid cytoplasmic protein that is ubiquitously expressed. TRP14 modulates TNFα signaling and NFκB activation. Suggested to have peroxidase activity, TRP14 may contribute to the elimination of cellular hydrogen peroxide.
