Cadherins are members of a multigene family of single chain glycoprotein receptors mediating calcium dependent cell-cell adhesion, which play important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. And cadherins play important role in tumor invasion and metastasis. Individual cadherin molecules are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein.
