Vascular endothelial growth factor A (VEGFA) is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often found as a disulfide linked homodimer. This protein has various functions, such as inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilization of blood vessels. It has many variants encoding either freely secreted or cell-associated isoforms, including VEGF-165 and VEGF-145.
