Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the phosphorylation of glyceralde-hyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue , GAPDH is thought to be a constitutively expressed housekeeping protein. For this reason, GAPDH mRNA and protein levels are often measured as controls in experiments quantifying specific changes in expression of other targets. Recent work has elucidated roles for GAPDH in apoptosis , gene expres-sion and nuclear transport . GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimer’s diseases.
