GATA-3 belongs to the GATA family of transcription factors. It regulates luminal epithelial cell differentiation in the mammary gland. GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 cells towards this Th2 cell subtype while suppressing their differentiation towards Th1 cells. GATA-3 was shown to directly regulate luminal cell differentiation in mouse models of breast cancer. It is also considered a strong predictor of taxane and platin salts insensitivity. GATA3 has been shown to interact with LMO1, ER and FOXA1.
