Insulin-like growth factor 2 (IGF-2) receptor, also widely known as M6PR, is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-2 from the plasma membrane. M6PR functions to clear IGF2 from the cell surface to attenuate signalling, and to transport lysosomal acid hydrolase precursors from the Golgi apparatus to the lysosome. After binding IGF2 at the cell surface, M6PRs accumulate in forming clathrin-coated vesicles and are internalized. In the lumen of the trans-Golgi network, the M6PR binds M6P-tagged cargo. In several research studies, M6PR has been recognized as a tumor suppressor in a number of cancers.
