This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant.Glutathione reductase, also designated Glutathione reductase mitochondrial precursor, GRase, GSR or GR, belongs to the class-I pyridine nucleotidedisulfide oxidoreductase family. The main function of the protein is to maintain high levels of reduced Glutathione in the cytosol.
