This gene encodes a transcription factor containing an ETS DNA-binding domain.Friend leukemia virus integration1 (FLI1) that is also termed EWSR2 encodes a sequence-specific transcriptional activator involved in Ewing’s sarcoma (EWS), a malignant small, round, blue cell tumour.It is a rare disease in which cancer cells are found in the bone or in soft tissue. FLI1 protein may act as an aberrant transcription factor, but exact mechanisms of oncogenesis remains unknown.
