This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. It is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p12.1. Human DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion.
