YTHDF2 also named as CLL associated antigen KW 14 or HGRG8 is a 579 amino acid protein, which contains one YTH domain and exists as two alternatively spliced isoforms. YTHDF2 is expressed in in pancreas, testis and placenta.YTHDF2 Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity.