Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response.The protein encoded by this gene is a class I catalytic subunit of PI3K.Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K.This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
