Dystrophin (DMD or BMD) is a large muscle protein that forms the dystrophin glycoprotein complex (DGC), bridging the internal cytoskeleton and extracellular matrix. DMD anchors the extracellular matrix to the cytoskeleton through F-actin and is a ligand for Dystroglycan. DMD mutations can cause Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), which are childhood muscle diseases that lead to progressive muscle weakness, dependency disorders, and muscle weakness caused by intravascular cardiovascular disease.
