Small GTPases Rab are key regulators of intracellular membrane transport, from the formation of transport vesicles to fusion with the membrane. The RABS cycle operates between the inactive GDP binding form and the active GTP binding form, which can recruit different downstream effect subsets on the membrane and directly responsible for vesicle formation, movement, binding, and fusion. Rab5A is involved in multiple processes, including the clearance rate of amyloid beta through cross cell bacterial disease; Early to late endosomal transport; Regulation of exocytosis.
