Zeta associated protein (zap) -70 is a member of the Syk family of tyrosine kinases, which plays an important role in T cell receptor signal transduction, NK cell activation and early B cell development. ZAP-70 plays an important role in regulating adaptive immune response. It can regulate the movement, adhesion and cytokine expression of mature T cells, as well as the development of thymocytes, and also contribute to the development and activation of primary B lymphocytes. In addition, ZAP70 controls the cytoskeleton modification, adhesion and migration of T lymphocytes, thus ensuring the correct delivery of effectors to APC. ZAP70 also participates in the internalization and degradation of tcr-cd247/cd3z through the interaction with E3 ubiquitin protein ligase CBL and adapter proteins SLA and sla2. Therefore, ZAP70 regulates the opening and closing of T cell activation switch by regulating the expression of TCR on T cell surface.
