NUTT1 (NUT Midline Cancer Family Member 1) is a gene located in the q14 region of human chromosome 15. Its encoded NUT protein is specifically expressed only in sperm cells after testicular meiosis under physiological conditions. Its core function is to participate in chromatin condensation by regulating histone acetylation, which is crucial for male reproductive function. It plays a role in proliferation regulation. Regulating TERT expression by modulating the binding site between SP1 and TERT promoter.
