CREB-binding protein, also known as CREBBP or CBP, carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: RID, KIX, TAZ1/CH1 and TAZ2/CH3 and IBiD. CBP shares regions of very high-sequence similarity with protein EP300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation.
