EOMES(eomesodermin homolog), also known as TBR2 (T-box-brain2), encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. Recent evidence suggests that EOMES and IPCs may also play a role neurogenesis in the adult hippocampal SGZ. EOMES is also a key transcription factor for memory T cells and for full effector differentiation of CD8+ T cells. Expression of EOMES is induced in CD8+ T cells following viral infection and bacterial infection where sufficient IL-12 has been produced to elicit acute host cell response.
