ALP (actinin-associated LIM protein), also known as PDLIM3 (PDZ and LIM domain protein 3) is a 364 amino acid protein that contains one LIM zinc-binding domain and one PDZ domain and localizes to the cytoplasm, as well as to myofiber Z-lines. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene.
