Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. Atg13 (ATG13 autophagy related 13 homolog) is a 517 amino acid hosphoprotein
belonging to the ATG13 metazoan family.Atg13 functions as an autophagy factor required for autophagosome formation. Atg13 is a target of the TOR kinase signaling pathway, which mediates autophagy by controlling phosphorylation of Atg13 and ULK1, and by regulating the Atg13-ULK1-RB1CC1 complex.Atg13 also functions as a component of another complex, the ULK1-Atg13 complex, which regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.
