The TGFβ RI forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. TGFβ RI is a 503 amino acid single-pass type I membrane protein that is expressed ubiquitously and, with TGFβ RII, functions as a receptor for TGFβ. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
