This G-protein coupled receptor inhibits adenylyl cyclase activity. D(2) dopamine receptor (dopamine D2 receptor) is one of the five types (D1 to D5) of receptors for dopamine. Genetic variations in the dopamine D2 receptor are implicated in the genetic susceptibility to alcoholism. Genetic variations in the dopamine D2 receptor are a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.
