Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites. MAP2 binds in a cooperative manner, with many MAP2 proteins binding a single microtubule to promote stabilization. Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B, and low molecular weight MAP2C and MAP2D. . The suppression of microtubule dynamic instability by the MAP proteins is thought to be associated with phosphorylation of the MAPs.
