ADAMs is a member of the ADAM (a disintegrin and metalloprotease domain) family.Ppreproprotein is proteolytically processed to generate the mature protease.encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. protein also plays a prominent role in the activation of the Notch signaling pathway.
