The product of this gene belongs to the integrin alpha chain family.Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling.The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit.This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits.The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor.This integrin may regulate angiogenesis and cancer progression.Alternative splicing results in multiple transcript variants.Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
