This gene encodes a member of the DNA mismatch repair MutS family. MutS protein helps in the recognition of mismatched nucleotides prior to their repair.The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated.Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer.
