Succinylation is a post-translational modification in which succinyl groups are added to lysine residues of protein molecules. The potential role of succinylation is currently being studied, but with the addition of succinyl groups, the charge of lysine changes from+1 to -1 (at physiological pH), and a relatively large structural portion is introduced, larger than acetylation or methylation, which is expected to lead to more significant changes in protein structure and function. ANXA6， Also known as CBP68, it belongs to the calcium dependent membrane and phospholipid binding protein family. Several members of the membrane associated protein family are involved in membrane related events in bothextracellular and intracellular pathways. Membrane associated protein VI is involved in mediating the endosome aggregation and vesicle fusion of secretory epithelial cells during exocytosis. It may be related to CD21. It can regulate the release of calcium within cells.
