Angiopoietin-2 (ANG2) is a growth factor belonging to the angiopoietin/TIE (with IG and EGF homology domains), which is one of the main pathways involved in angiogenesis. Angiopoietin-2 is a natural antagonist of TIE2, which disrupts angiogenesis in the body. In adult mice and humans, angiopoietin-2 is only expressed at the site of vascular remodeling. Angiogenesis 2 is upregulated in various inflammatory diseases and is associated with direct control of signaling pathways related to inflammation. The encoded protein can affect angiogenesis during embryonic and tumor development, disrupt the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis.
