NBL1, neuroblastoma suppressor of tumorigenicity 1,also known as zinc finger protein DAN, NO3, DAND1, is a secreted protein containing one C-terminal cysteine knot-like (CTCK) domain. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1. In addition to antagonizing BMP signaling, DAN also antagonizes the action of TGF. DAN is a possible tumor suppressor for human neuroblastoma; defects may result in or contribute to its progression. DAN may also be a neuromodulator in inflammatory pain.
