Wang J; Huang Q; Hu X, et al., Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer. Cancer Res 2022, 82 (8), 1503-1517.
Wang S; Wu H; Shi X, et al., Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis. Sci Total Environ 2023, 165461.
Wang H; Liang W; Wang X, et al., Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development. Cell Mol Biol Lett 2023, 28 (1), 50.
Zhang M; Li L; Li S, et al., Development of Clioquinol Platinum(IV) Conjugates as Autophagy-Targeted Antimetastatic Agents. J Med Chem 2023, 66 (5), 3393-3410.
Lv W; Ren G; Shimizu K, et al., Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition. Food Science and Human Wellness 2023.
Zhang T; Kang H; Peng Q, et al., Therapeutic mechanism of Cornus Officinalis Fruit Coreon on ALI by AKT/Nrf2 pathway and gut microbiota. Phytomedicine 2024, 130, 155736.
Li M; Zhang Y; Zhou J, et al., Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis. Antioxidants 2022, 11 (11), 2105.
Wang Y; An X; Wang F, et al., Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3. Biomed Pharmacother 2024, 172, 116253.
Fan M; Liu S; Sun H M, et al., Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammation. Biomed Pharmacother 2022, 153, 113375.
Xg A; Yao Q A; Xl A, et al., A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing. 2021.
Zhang Z; Xia F; Yao L, et al., circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis. Front Cell Dev Biol 2022, 10, 817028.
Liu Y; Luo Y; Shi X, et al., Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. Biochim Biophys Acta Mol Basis Dis 2023, 1869 (7), 166794.
Zhao X; Li Z; Guo Y, et al., Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats. Anesth Analg 2023.
Song N; Wang W; Wang Y, et al., Hydrogen sulfide of air induces macrophage extracellular traps to aggravate inflammatory injury via the regulation of miR-15b-5p on MAPK and insulin signals in trachea of chickens. Sci Total Environ 2021, 771, 145407.
Li Z; Xu T; Fan X, et al., Bisphenol A aggravate selenium deficiency-induced apoptosis via miR-215-3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial. J Cell Physiol 2023.
Cui W; Zhou S; Wang Y, et al., Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue. Ecotoxicol Environ Saf 2021, 228, 113015.
Yu L; Li L; Liu J, et al., Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration. International Journal of Molecular Sciences 2022, 23 (18), 10584.
Zhan M; Liu D; Yao L, et al., Gas6/AXL Alleviates Hepatic Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the PI3K/AKT Pathway. Transplantation 2024.
Zhang W; Xia L; Ren X, et al., The improved targeting of an aspirin prodrug albumin-based nanosystem for visualizing and inhibiting lung metastasis of breast cancer. Biomater Sci 2020, 8 (21), 5941-5954.
Li X; Duan J; Wang S, et al., Isorhamnetin protects porcine oocytes from zearalenone-induced reproductive toxicity through the PI3K/Akt signaling pathway. J Anim Sci Biotechnol 2023, 14 (1), 22.
Wang X J; Qi L; Cheng Y F, et al., PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease. Acta Pharmacol Sin 2021.
Qiu L; Gao Q; Liao Y, et al., Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma. J Transl Med 2025, 23 (1), 145.
Li X; Jiang Z; Li J, et al., PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1/PI3K/AKT pathway. Apoptosis 2024.
Li Q; Huang X; Li Q Y, et al., CENPH overexpression promotes the progression, cisplatin resistance, and poor prognosis of lung adenocarcinoma via the AKT and ERK/P38 pathways. Am J Cancer Res 2023, 13 (5), 1682-1697.
Wang X; Cao X; Dong D, et al., Circular RNA TTN Acts As a miR-432 Sponge to Facilitate Proliferation and Differentiation of Myoblasts via the IGF2/PI3K/AKT Signaling Pathway. Mol Ther Nucleic Acids 2019, 18, 966-980.
Chen S; Wu F; Yang C, et al., Alternative to Sugar, Honey Does Not Provoke Insulin Resistance in Rats Based on Lipid Profiles, Inflammation, and IRS/PI3K/AKT Signaling Pathways Modulation. J Agric Food Chem 2022, 70 (33), 10194-10208.
Wang Y; Sun C; Huang L, et al., Magnolol-loaded cholesteryl biguanide conjugate hydrochloride nanoparticles for triple-negative breast cancer therapy. Int J Pharm 2022, 615, 121509.
Wu Y; Xu X; Liu M, et al., DZW-310, a novel phosphoinositide 3-kinase inhibitor, attenuates the angiogenesis and growth of hepatocellular carcinoma cells via PI3K/AKT/mTOR axis. Biochem Pharmacol 2022, 201, 115093.
Li Z X; Sheng X D; Wang Y L, et al., Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway. Int Immunopharmacol 2022, 113 (Pt A), 109326.
Li Y; Yan W; Qin Y, et al., The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway. Int J Mol Sci 2024, 25 (12).
Wu J; Cui Y; Ding W, et al., The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway. Int Immunopharmacol 2024, 133, 112086.
Xing K; Che Y; Wang Z, et al., Chitosan nanoparticles encapsulated with BEZ235 prevent acute rejection in mouse heart transplantation. Int Immunopharmacol 2023, 124 (Pt A), 110922.
Cao P; Nie G; Luo J, et al., Cadmium and molybdenum co-induce pyroptosis and apoptosis via the PTEN/PI3K/AKT axis in the livers of Shaoxing ducks (Anas platyrhynchos). Food Funct 2022.
Zhang Z; Li Z; Wang Y, et al., PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis. J Mater Chem B 2021, 9 (31), 6176-6189.
Li X; Chen H; Zhang Z, et al., Isorhamnetin protects zearalenone-induced damage via the PI3K/Akt signaling pathway in porcine ovarian granulosa cells. Animal Nutrition 2022.
Yang J; Li X; Tong Y, et al., Targeting co-delivery of doxorubicin and gefitinib by biotinylated Au NCs for overcoming multidrug resistance in imaging-guided anticancer therapy. Colloids Surf B Biointerfaces 2022, 217, 112608.
Wang L; Liu Y; Li S, et al., Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway. Aging (Albany NY) 2023, 15 (21), 11845-11859.
Zhu S; Wen H; Wang W, et al., Anti-hepatitis B virus activity of lithospermic acid, a polyphenol from Salvia miltiorrhiza, in vitro and in vivo by autophagy regulation. J Ethnopharmacol 2022, 302 (Pt A), 115896.
Di Y Q; Zhao Y M; Jin K Y, et al., Subunit P60 of phosphatidylinositol 3-kinase promotes cell proliferation or apoptosis depending on its phosphorylation status. PLoS Genet 2021, 17 (4), e1009514.
Huang B; Wang H; An Z, et al., Compromised Peroxisome Proliferator-Activated Receptor gamma-Mediated Impaired Placental Glucose Transport Via the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway Is Associated With Fetal Growth Restriction. Lab Invest 2025, 105 (4), 104103.
Ling J; Li X; Wang M, et al., Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway. Bioorg Chem 2024, 143, 107069.
Fan J; Zhou Q; Li Y, et al., Profiling of Long Non-coding RNAs and mRNAs by RNA-Sequencing in the Hippocampi of Adult Mice Following Propofol Sedation. Front Mol Neurosci 2018, 11, 91.
"Huang G; An L; Fan M, et al., Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification. J Mol Cell Cardiol 2020, 141, 93-104.
Lin M; Xie W; Xiong D, et al., Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3beta (Ser9)/Nrf2 pathway. Chin Med 2023, 18 (1), 136.
Li C; Qin T; Jin Y, et al., Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway. J Orthop Translat 2023, 39, 124-134.
Hao R; Ge J; Ren Y, et al., Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity in mice: Role of miR-182-5p/TLR4 axis. Ecotoxicol Environ Saf 2021, 207, 111578.
Chen J; Liu F; Wu J, et al., Effect of STK3 on proliferation and apoptosis of pancreatic cancer cells via PI3K/AKT/mTOR pathway. Cell Signal 2023, 106, 110642.
Sanches J G P; Song B; Zhang Q, et al., The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway. Front Oncol 2021, 11, 637298.
Wang M; Yan J; Cao X, et al., Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1alpha activation. Biochem Pharmacol 2020, 172, 113775.
Yang W; Qiu J; Zi J, et al., Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K/AKT pathway and targeting EGFR/ALB in rats. J Ethnopharmacol 2024, 338 (Pt 1), 119020.
Li H; Liu Y; Zhang H, et al., Identification of potential diagnostic biomarkers and therapeutic targets in patients with hypoxia pulmonary hypertension. Int Immunopharmacol 2024, 142 (Pt A), 113028.
Sun S; Li M; Wang M, et al., Anti-photoaging effect and the mechanism of Coreopsis tinctoria okanin against UVB-induced skin damage in mice. Int Immunopharmacol 2024, 139, 112657.
Ruan H; Luo J; Wang L, et al., Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling. Int J Biol Macromol 2019, 141, 961-987.
Gong W J; Liu J Y; Yin J Y, et al., Resistin facilitates metastasis of lung adenocarcinoma through the TLR4/Src/EGFR/PI3K/NF-kappaB pathway. Cancer Sci 2018, 109 (8), 2391-2400.
Deng X; Que Q; Zhang K, et al., Mechanistic insights into the role of EGLN3 in pulmonary vascular remodeling and endothelial dysfunction. Respir Res 2025, 26 (1), 61.
Li X; Cheng J; Yao Q, et al., Isorhamnetin Improves Oocyte Maturation by Activating the Pi3k/Akt Signaling Pathway. Mol Nutr Food Res 2024, 68 (15), e2300904.
Jia J; Wang N; Zheng Y, et al., RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. J Cell Mol Med 2021, 25 (11), 5070-5081.
Cui Y H; Fu A; Wang X Q, et al., Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress. Neuropharmacology 2020, 184, 108410.
Huang M S; Liu J Y; Xia X B, et al., Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway. Front Oncol 2019, 9, 508.
Su Y; Li T; He X, et al., PI3K/AKT pathway modulation and cold acclimation alleviation concerning apoptosis and necroptosis in broiler thymus. Poult Sci 2024, 103 (5), 103634.
Yang R; Xu S; Zhang X, et al., Cyclocarya paliurus triterpenoids attenuate glomerular endothelial injury in the diabetic rats via ROCK pathway. J Ethnopharmacol 2022, 115127.
Li J J; Wang C M; Wang Y J, et al., Network pharmacology analysis and experimental validation to explore the mechanism of Shenlian extract on myocardial ischemia. J Ethnopharmacol 2022, 288, 114973.
Liu Y; Zhao H; Yin K, et al., The protective effect of Zn2+ on As3+ toxicity in common carp: Resistance to oxidative stress, inhibition of endoplasmic reticulum stress, apoptosis and autophagy. Aquaculture 2022, 546, 737375.
Li H; Liu Y; Shi X, et al., SP1/ADAM10/DRP1 axis links intercellular communication between smooth muscle cells and endothelial cells under hypoxia pulmonary hypertension. Biochim Biophys Acta Mol Basis Dis 2025, 1871 (4), 167720.
Wang M; Cao X; Luan C, et al., Hydrogen Sulfide Attenuates Hydrogen Peroxide-Induced Injury in Human Lung Epithelial A549 Cells. Int J Mol Sci 2019, 20 (16).
Wei X; Yang B; Chen X, et al., Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways. Food Funct 2021, 12 (8), 3740-3753.
Xu Y; He Z; Li Z, et al., Irgm1 is required for the inflammatory function of M1 macrophage in early experimental autoimmune encephalomyelitis. J Leukoc Biol 2017, 101 (2), 507-517.
Li Y; Wang Z; Li J, et al., Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo. Biol Trace Elem Res 2023.
Chen Z; Wang J; Fan Z, et al., Effects of polysaccharide from the fruiting bodies of Auricularia auricular on glucose metabolism in (60)Co-gamma-radiated mice. Int J Biol Macromol 2019, 135, 887-897.
Liu Y; Chen H; Fan W, et al., Fasting time after feeding affects the evaluation of metabolic response in abalone Haliotis discus hannai to nutrients using dietary methionine as an example. Aquaculture 2025, 594, 741473.
Qiao Y; Xu L; Tao X, et al., Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett 2018, 284, 37-45.
Li M; Wang Y; Wang Q, et al., A Mutant of Africa Swine Fever Virus Protein p72 Enhances Antibody Production and Regulates the Production of Cytokines. Viruses 2025, 17 (2).
Li J; Li Z; Cui M, et al., Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition. Journal of Functional Foods 2025, 124, 106646.
Zhang Q; Su G; Zhao T, et al., Neuroprotection of round scad (Decapterus maruadsi) hydrolysate in glutamate-damaged PC12 cells: Possible involved signaling pathways and potential bioactive peptides. Journal of Functional Foods 2019, 64, 103690.
Li F; Song X; Xu J, et al., Morroniside protects OLN-93 cells against H2O2-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities. Cell Cycle 2021, 20 (7), 661-675.
Fei Y; Zhao B; Zhu J, et al., XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3beta/beta-catenin/VEGF signal in mice exposed to cerebral ischemic injury. Life Sci 2021, 272, 119234.
Zhao B; Zhu J; Fei Y, et al., JLX001 attenuates blood-brain barrier dysfunction in MCAO/R rats via activating the Wnt/beta-catenin signaling pathway. Life Sci 2020, 260, 118221.
Zhang J; Li C; Li W, et al., Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments. Front Oncol 2024, 14, 1471109.
Xu D; Hou K; Li F, et al., XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/beta-catenin signaling dependent way. Life Sci 2019, 235, 116844.
Ren H; Feng J; Hong M, et al., Baicalein attenuates oxidative damage in mice haematopoietic cells through regulation of PDGFRbeta. Mol Cell Probes 2024, 76, 101966.
Gou L; Liu M; Xia J, et al., BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1. Int J Mol Sci 2018, 19 (4).
Tian W; Pang W; Ge Y, et al., Hepatocyte-generated 27-hydroxycholesterol promotes the growth of melanoma by activation of estrogen receptor alpha. J Cell Biochem 2018, 119 (3), 2929-2938.
Yiming Z; Zhaoyi L; Jing L, et al., Cadmium induces the thymus apoptosis of pigs through ROS-dependent PTEN/PI3K/AKT signaling pathway. Environ Sci Pollut Res Int 2021.
Wen J; Zhang Y Q; Liu D Q, et al., Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease. Chin J Nat Med 2022, 20 (2), 111-119.