Wu K; Liu Y; Xia J, et al., Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid. Adv Sci (Weinh) 2023, e2304408.
Li S; Yang M; Zhao Y, et al., Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation. Nat Commun 2024, 15 (1), 8425.
Hu W, Qian X, Lin X, et al.,Zeolitic imidazolate frameworks exert bioenergetic modulation via the cAMP/PKA/CREB signaling pathway to accelerate periodontal regeneration.Chemical Engineering Journal (2025): 171251.
Yu Q; Sun H; Yue Z, et al., Zwitterionic Polysaccharide-Based Hydrogel Dressing as a Stem Cell Carrier to Accelerate Burn Wound Healing. Adv Healthc Mater 2022, e2202309.
Gou Y; Weng Y; Chen Q, et al., Carboxymethyl chitosan prolongs adenovirus-mediated expression of IL-10 and ameliorates hepatic fibrosis in a mouse model. Bioengineering & Translational Medicine 2022, 7 (3), e10306.
Li L; Sun H; Chen J, et al., Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARgamma-Cd36 pathway. Cell Rep 2023, 42 (7), 112697.
Yao H; Zhang L; Yan S, et al., Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of BMSCs through microfilaments and TRPM7. J Nanobiotechnology 2022, 20 (1), 378
Wang F; Qin K; Wang K, et al., Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells. Cell Rep 2022, 39 (12), 110981.
Zhang T; Yang F; Dai X, et al., Role of Caveolin-1 on the molybdenum and cadmium exposure induces pulmonary ferroptosis and fibrosis in the sheep. Environ Pollut 2023, 334, 122207.
Ji D N; Jin S D; Jiang Y, et al., CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/beta-catenin signaling pathway. Acta Pharmacol Sin 2024.
Lin S; Quan G; Hou A, et al., Strategy for hypertrophic scar therapy: Improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array. J Control Release 2019, 306, 69-82.
Zhang W; Wang Q; Xing X, et al., The antagonistic effects and mechanisms of microRNA-26a action in hypertensive vascular remodelling. Br J Pharmacol 2021, 178 (5), 1037-1054.
Cao C; Lin F; Li X, et al., Fumonisin B1 induces hepatotoxicity in mice through the activation of oxidative stress, apoptosis and fibrosis. Chemosphere 2022, 133910.
Wu X, Li J, Dong Y, et al., Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis. Food Frontiers 7.2 (2026): e70136.
Zhang W; Zhang Q; Zhu Y, et al., Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPARgamma pathway. Life Sci 2022, 120972.
Guo J ; Liu H ; Jin T ,et al.,Moslae Herba extract alleviates hyperuricemia by regulating uric acid metabolism and relieving renal inflammation and fibrosis in mice.Phytomedicine, 2025, 145.
Wang W; Li Y; Zhang C, et al., Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4. International Journal of Nanomedicine 2025, 557-579.
Fu Y; Wan P; Zhang J, et al., Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway. Front Cell Dev Biol 2021, 9, 741060.
Wang C; Liu S; Li J, et al., Biological Functions of Let-7e-5p in Promoting the Differentiation of MC3T3-E1 Cells. Front Cell Dev Biol 2021, 9, 671170.
Ding Y; Wang L; Liu B, et al., Bryodulcosigenin attenuates bleomycin-induced pulmonary fibrosis via inhibiting AMPK-mediated mesenchymal epithelial transition and oxidative stress. Phytother Res 2022.
Chen T; Guo Y; Wang J, et al., LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation. Cell Death Dis 2021, 12 (6), 600.
Zhao Y; Xu T; Ye C, et al., Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53. Phytother Res 2026, 40 (3), 965-985.
Cui W; Zhou S; Wang Y, et al., Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue. Ecotoxicol Environ Saf 2021, 228, 113015.
Wang Y; Liao J; Luo Y, et al., Berberine Alleviates Doxorubicin-Induced Myocardial Injury and Fibrosis by Eliminating Oxidative Stress and Mitochondrial Damage via Promoting Nrf-2 Pathway Activation. Int J Mol Sci 2023, 24 (4).
Gao Z; Li M; Yao F, et al., Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma. International Journal of Molecular Sciences 2022, 23 (21), 12983.
Wang L; Du A; Lu Y, et al., Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-beta-Catenin Signaling Axis. J Am Heart Assoc 2023, 12 (10), e028866.
Duan Q; Liu Z; Xing Y, et al., Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-beta1/IL-11 in cerebral small vessel disease. J Transl Med 2025, 23 (1), 161.
Zou Y Y; Tang X B; Chen Z L, et al., Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish. Front Endocrinol (Lausanne) 2023, 14, 1162485.
Wang L, Geng J, Wang H. Delivery of Oleanolic Acid with Improved Antifibrosis Efficacy by a Cell Penetrating Peptide P10[J]. ACS Pharmacology & Translational Science, 2023.
Liao J; Li K; Su X, et al., Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through alpha2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice. Int J Mol Sci 2021, 22 (23).
Li T; Xiong X; Wang Y, et al., Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/beta-catenin signaling pathway. iScience 2023, 26 (10), 107888.
Han Q J; Mu Y L; Zhao H J, et al., Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells. World J Gastroenterol 2021, 27 (24), 3581-3594.
He X; Chen S; Li C, et al., Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages. Cells 2020, 9 (1).
Ma P; Guo Y Z; Wang L L, et al., Dopamine receptor D2 regulates inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis disease. Biochem Pharmacol 2026, 245, 117696.
Jing H; Wang S; Wang Y, et al., Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken. Sci Total Environ 2020, 726, 138686.
Deng H; Tian X; Sun H, et al., Calpain-1 mediates vascular remodelling and fibrosis via HIF-1alpha in hypoxia-induced pulmonary hypertension. J Cell Mol Med 2022.
Yan Q; Pan L; Qi S, et al., RNF2 Mediates Hepatic Stellate Cells Activation by Regulating ERK/p38 Signaling Pathway in LX-2 Cells. Front Cell Dev Biol 2021, 9, 634902.
Wang C; Wang S; Liu S, et al., Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells. Front Cell Dev Biol 2020, 8, 623.
Cui Y; Song M; Xiao B, et al., ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice. Chem Biol Interact 2021, 349, 109663.
"Huang G; An L; Fan M, et al., Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification. J Mol Cell Cardiol 2020, 141, 93-104.
Yan W; Wang L; Zhu W, et al., Liquiritigenin alleviates high-salt diet-induced heart damage by inhibiting TGF-β1/Smad signaling and reducing inflammation and fibrosis. The Journal of Nutritional Biochemistry, 2025: 110151.
Zheng Z; Li Z; Liu X, et al., Rapamycin ameliorates senescence of periodontal ligament stem cells and promotes their osteogenesis via the PI3K/AKT pathway. Int Immunopharmacol 2025, 153, 114517.
Guo Q; Yang A; Zhao R, et al., Nimodipine ameliorates liver fibrosis via reshaping liver immune microenvironment in TAA-induced in mice. Int Immunopharmacol 2024, 138, 112586.
Ma Z; Hao J; Yang Z, et al., Lilrb2-mediated inhibition of scleral remodeling in experimental myopia is associated with reduced intraocular inflammation and modulation of the MEK-ERK-P65 axis. Eur J Pharmacol 2026, 1011, 178458.
Zhong G; Qiao B; He Y, et al., Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis. Pestic Biochem Physiol 2024, 201, 105904.
Deng M; Yang S; Ji Y, et al., Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts. J Cell Mol Med 2020, 24 (9), 5249-5259.
Jin Y; Wang Y; Weng Y, et al., Resveratrol exhibits inhibition effects on osteogenic differentiation of aortic valve interstitial cells by interfering with the AKT pathway. Journal of Functional Foods 2022, 91, 105002.
Zu T; Yang H; Wang J, et al., Inhibition of METTL3 Attenuates Renal Fibrosis by Upregulating ABCG2 m6A Modifications via IGF2BP2-Dependent Mechanisms in Hyperuricemic Nephropathy. J Cell Mol Med 2025, 29 (6), e70468.
Jiang Q Q; Du C; Qian L L, et al., GPX3 Overexpression Ameliorates Cardiac Injury Post Myocardial Infarction Through Activating LSD1/Hif1alpha Axis. J Cell Mol Med 2025, 29 (3), e70398.
Yuan W; Qiu T; Yao X, et al., Hsp47 acts as a bridge between NLRP3 inflammasome and hepatic stellate cells activation in arsenic-induced liver fibrosis. Toxicol Lett 2022.
Jiang Z; Yang F; Cao H, et al., Deltamethrin exposure caused renal inflammation and renal fibrosis via upregulating endoplasmic reticulum stress-mediated TXNDC5 level in mice. Pesticide Biochemistry and Physiology 2024, 106180.
Cui Y; Song M; Xiao B, et al., PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in the Bone Impairment Caused by Aluminum Exposure. J Agric Food Chem 2021, 69 (21), 6054-6063.
Zhang Y; Zhang J; Sun B, et al., Catalpol Promotes Osseointegration of Titanium Implants under Conditions of Type 2 Diabetes via AKT/GSK3β/FYN Pathway-Mediated NRF2 Activation. ACS Omega 2024.
Song X; Cui W; Gao Z, et al., Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl4-induced hepatotoxicity. Int Immunopharmacol 2021, 96, 107554.
Li R S; Xu G H; Cao J, et al., Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5'-Monophosphate-Activated Protein Kinase. Front Pharmacol 2019, 10, 1305.
Yang J Y; Tao L J; Liu B, et al., Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway. Front Pharmacol 2019, 10, 151.
Liu B; Yang J; Hao J, et al., Natural product mogrol attenuates bleomycin-induced pulmonary fibrosis development through promoting AMPK activation. Journal of Functional Foods 2021, 77 (8), 104280.
Zhang H ; Li M ; Zhao B ,et al., Evidence for Imbalanced Polarization of Caruncle Macrophages in Retained Placenta of Dairy Cows.Journal of Dairy Science 2025.
Yang J; Zhang W; Lin B, et al., Enhancement of Local Osseointegration and Implant Stability of Titanium Implant in Osteoporotic Rats by Biomimetic Multilayered Structures Containing Catalpol. ACS Omega 2024, 9 (27), 29544-29556.
Zhang M; Wang H; Wang X, et al., MG53/CAV1 regulates transforming growth factor-beta1 signaling-induced atrial fibrosis in atrial fibrillation. Cell Cycle 2020, 19 (20), 2734-2744.
He Y; Shuai R; Wu J, et al., Unveiling the ITGbeta1-CLIC1 axis: a new frontier in oral squamous cell carcinoma progression and immune evasion: insights from the tumor-mimetic ECM system. BMC Cancer 2025, 26 (1), 8.
Wang Z; Tao Y; Qiu T, et al., Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARalpha-autophagy pathway. Chem Biol Interact 2019, 300, 123-130.
Li X; Wang H F; Li X X, et al., Contribution of acid sphingomyelinase to angiotensin II-induced vascular adventitial remodeling via membrane rafts/Nox2 signal pathway. Life Sci 2019, 219, 303-310.
Yao H; Tang L; Wang D, et al., F-actin microfilaments affect the LIPUS-promoted osteogenic differentiation of BMSCs through TRPM7. Biotechnol J 2024, 19 (8), e2400310.
Ding Q; Sun J; Xie W, et al., Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages. Int Immunopharmacol 2019, 72, 385-394.
Fan Y S; Li Q; Hamdan N, et al., Tetrahydroxystilbene Glucoside Regulates Proliferation, Differentiation, and OPG/RANKL/M-CSF Expression in MC3T3-E1 Cells via the PI3K/Akt Pathway. Molecules 2018, 23 (9).
Song Y; Liu W; Tang K, et al., Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway. J Diabetes Res 2020, 2020, 9481720.