Wang J; Huang Q; Hu X, et al., Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer. Cancer Res 2022, 82 (8), 1503-1517.
Guo Y; Wen J; He A, et al., iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation. Journal of Advanced Research 2022.
Zhang M; Li L; Li S, et al., Development of Clioquinol Platinum(IV) Conjugates as Autophagy-Targeted Antimetastatic Agents. J Med Chem 2023, 66 (5), 3393-3410.
Lv W; Ren G; Shimizu K, et al., Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition. Food Science and Human Wellness 2023.
Zhang T; Kang H; Peng Q, et al., Therapeutic mechanism of Cornus Officinalis Fruit Coreon on ALI by AKT/Nrf2 pathway and gut microbiota. Phytomedicine 2024, 130, 155736.
Li M; Zhang Y; Zhou J, et al., Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis. Antioxidants 2022, 11 (11), 2105.
Wang Y; An X; Wang F, et al., Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3. Biomed Pharmacother 2024, 172, 116253.
Xg A; Yao Q A; Xl A, et al., A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing. 2021.
Zhang Z; Xia F; Yao L, et al., circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis. Front Cell Dev Biol 2022, 10, 817028.
Liu W; Wu F; Bi X, et al., Herbal formula Jiawei Xiaochengqi decoction prevents postoperative abdominal adhesion in a rat model through inhibition of CXCL2-CXCR2 pathway. Phytomedicine 2023, 154662.
Liu Y; Luo Y; Shi X, et al., Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. Biochim Biophys Acta Mol Basis Dis 2023, 1869 (7), 166794.
Song N; Wang W; Wang Y, et al., Hydrogen sulfide of air induces macrophage extracellular traps to aggravate inflammatory injury via the regulation of miR-15b-5p on MAPK and insulin signals in trachea of chickens. Sci Total Environ 2021, 771, 145407.
Zhang P; Fu H J; Lv L X, et al., WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis. Commun Biol 2023, 6 (1), 361.
Li Z; Xu T; Fan X, et al., Bisphenol A aggravate selenium deficiency-induced apoptosis via miR-215-3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial. J Cell Physiol 2023.
Li C; Hong P P; Yang M C, et al., FOXO regulates the expression of antimicrobial peptides and promotes phagocytosis of hemocytes in shrimp antibacterial immunity. PLoS Pathog 2021, 17 (4), e1009479.
Yu L; Li L; Liu J, et al., Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration. International Journal of Molecular Sciences 2022, 23 (18), 10584.
Zhang W; Xia L; Ren X, et al., The improved targeting of an aspirin prodrug albumin-based nanosystem for visualizing and inhibiting lung metastasis of breast cancer. Biomater Sci 2020, 8 (21), 5941-5954.
Li X; Duan J; Wang S, et al., Isorhamnetin protects porcine oocytes from zearalenone-induced reproductive toxicity through the PI3K/Akt signaling pathway. J Anim Sci Biotechnol 2023, 14 (1), 22.
Lu Y, Huang R, Sun Z, et al. A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes[J]. Food & Function, 2023.
Li Q; Huang X; Li Q Y, et al., CENPH overexpression promotes the progression, cisplatin resistance, and poor prognosis of lung adenocarcinoma via the AKT and ERK/P38 pathways. Am J Cancer Res 2023, 13 (5), 1682-1697.
Chen S; Wu F; Yang C, et al., Alternative to Sugar, Honey Does Not Provoke Insulin Resistance in Rats Based on Lipid Profiles, Inflammation, and IRS/PI3K/AKT Signaling Pathways Modulation. J Agric Food Chem 2022, 70 (33), 10194-10208.
Wang Y; Sun C; Huang L, et al., Magnolol-loaded cholesteryl biguanide conjugate hydrochloride nanoparticles for triple-negative breast cancer therapy. Int J Pharm 2022, 615, 121509.
Wu Y; Xu X; Liu M, et al., DZW-310, a novel phosphoinositide 3-kinase inhibitor, attenuates the angiogenesis and growth of hepatocellular carcinoma cells via PI3K/AKT/mTOR axis. Biochem Pharmacol 2022, 201, 115093.
Wu J; Cui Y; Ding W, et al., The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway. Int Immunopharmacol 2024, 133, 112086.
Xing K; Che Y; Wang Z, et al., Chitosan nanoparticles encapsulated with BEZ235 prevent acute rejection in mouse heart transplantation. Int Immunopharmacol 2023, 124 (Pt A), 110922.
Huang C; Gao X; Shi Y, et al., Inhibition of Hepatic AMPK Pathway Contributes to Free Fatty Acids-Induced Fatty Liver Disease in Laying Hen. Metabolites 2022, 12 (9), 825.
Cao P; Nie G; Luo J, et al., Cadmium and molybdenum co-induce pyroptosis and apoptosis via the PTEN/PI3K/AKT axis in the livers of Shaoxing ducks (Anas platyrhynchos). Food Funct 2022.
Li X; Chen H; Zhang Z, et al., Isorhamnetin protects zearalenone-induced damage via the PI3K/Akt signaling pathway in porcine ovarian granulosa cells. Animal Nutrition 2022.
Wang L; Liu Y; Li S, et al., Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway. Aging (Albany NY) 2023, 15 (21), 11845-11859.
Xu F; Wu J; Hu Y, et al., Mechanisms of action underlying the effect of Tongsaimai on wound healing based on experimental and network pharmacology. J Ethnopharmacol 2023, 311, 116451.
Li H; Xin G; Zhou Q, et al., Qingkailing granule alleviates pulmonary fibrosis by inhibiting PI3K/AKT and SRC/STAT3 signaling pathways. Bioorg Chem 2024, 146, 107286.
Ling J; Li X; Wang M, et al., Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway. Bioorg Chem 2024, 143, 107069.
Li X; Yao Y; Wang J, et al., Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells. Aquatic Toxicology 2022, 106204.
Lin M; Xie W; Xiong D, et al., Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3beta (Ser9)/Nrf2 pathway. Chin Med 2023, 18 (1), 136.
Sanches J G P; Song B; Zhang Q, et al., The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway. Front Oncol 2021, 11, 637298.
Wang M; Yan J; Cao X, et al., Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1alpha activation. Biochem Pharmacol 2020, 172, 113775.
Ruan H; Luo J; Wang L, et al., Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling. Int J Biol Macromol 2019, 141, 961-987.
Li X; Cheng J; Yao Q, et al., Isorhamnetin Improves Oocyte Maturation by Activating the Pi3k/Akt Signaling Pathway. Mol Nutr Food Res 2024, 68 (15), e2300904.
Jia J; Wang N; Zheng Y, et al., RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. J Cell Mol Med 2021, 25 (11), 5070-5081.
Song X L; Fu H Y; Chen W., Effects of Flammulina velutipes polysaccharides on quality improvement of fermented milk and antihyperlipidemic on streptozotocin-induced mice. Journal of Functional Foods 2021, 87, 104834.
Meng J; Ma H; Zhu Y, et al., Dehydrocostuslactone attenuated oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway. Eur J Pharmacol 2021, 911, 174554.
Huang M S; Liu J Y; Xia X B, et al., Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway. Front Oncol 2019, 9, 508.
Su Y; Li T; He X, et al., PI3K/AKT pathway modulation and cold acclimation alleviation concerning apoptosis and necroptosis in broiler thymus. Poult Sci 2024, 103 (5), 103634.
Yang R; Xu S; Zhang X, et al., Cyclocarya paliurus triterpenoids attenuate glomerular endothelial injury in the diabetic rats via ROCK pathway. J Ethnopharmacol 2022, 115127.
Liu Y; Zhao H; Yin K, et al., The protective effect of Zn2+ on As3+ toxicity in common carp: Resistance to oxidative stress, inhibition of endoplasmic reticulum stress, apoptosis and autophagy. Aquaculture 2022, 546, 737375.
Wang M; Cao X; Luan C, et al., Hydrogen Sulfide Attenuates Hydrogen Peroxide-Induced Injury in Human Lung Epithelial A549 Cells. Int J Mol Sci 2019, 20 (16).
Wei X; Yang B; Chen X, et al., Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways. Food Funct 2021, 12 (8), 3740-3753.
Li Y; Wang Z; Li J, et al., Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo. Biol Trace Elem Res 2023.
Liu Z; Wang N; Ma Y, et al., Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice. Front Microbiol 2019, 10, 390.
Chen Z; Wang J; Fan Z, et al., Effects of polysaccharide from the fruiting bodies of Auricularia auricular on glucose metabolism in (60)Co-gamma-radiated mice. Int J Biol Macromol 2019, 135, 887-897.
Wang J; He X; Jia Z, et al., Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway. Pharm Biol 2024, 62 (1), 33-41.
Zhang Q; Su G; Zhao T, et al., Neuroprotection of round scad (Decapterus maruadsi) hydrolysate in glutamate-damaged PC12 cells: Possible involved signaling pathways and potential bioactive peptides. Journal of Functional Foods 2019, 64, 103690.
Li F; Song X; Xu J, et al., Morroniside protects OLN-93 cells against H2O2-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities. Cell Cycle 2021, 20 (7), 661-675.
Fei Y; Zhao B; Zhu J, et al., XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3beta/beta-catenin/VEGF signal in mice exposed to cerebral ischemic injury. Life Sci 2021, 272, 119234.
Zhao B; Zhu J; Fei Y, et al., JLX001 attenuates blood-brain barrier dysfunction in MCAO/R rats via activating the Wnt/beta-catenin signaling pathway. Life Sci 2020, 260, 118221.
Zhu M; Pu J; Zhang T, et al., Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway. Adipocyte 2024, 13 (1), 2381262.
Wen J; Zhang Y Q; Liu D Q, et al., Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease. Chin J Nat Med 2022, 20 (2), 111-119.
