Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene. Expressed in epithelial cells of proximal tubules in renal cortex, SLC22A12 is required for efficient urate re-absorption in the kidney, thereby regulating blood urate levels and mediating saturable urate uptake by facilitating the exchange of urate against organic anions. Lesinurad is an urate transporter inhibitor that has been approved to treat gout. Lesinurad enhances urate excretion by inhibition the tubular re-absorption. Probenecid also facilitates uric acid secretion.
